Discussion Post Response
Antiviral medications with activity against influenza viruses arre an important adjunct to influenza vaccine in the control of influenza. Oral Oseltamivir phosphate also known as Tamiflu is an neuraminidase inhibitor that block the viral neuraminidase enzyme and have activity against both influenza A and B viruses (Johnson, & Li, 2019). Tamiflu inhibits the neuraminidase enzyme, which is expressed on the viral surgace, the enzyme promotes release of virus from infected cells and facillitates viral movement within the respiratory tract (Lehnert, Pletz, Reuss, & Schaberg, 2016). When considering use of Tamiflu clinician must consider the patient’s age, weight and renal function. RCTs and meta-analyses of RCTs have indicated that gastrointestinal symptoms such as nausea and vomiting, headache, serious skin reactions, and sporadic transient neuropsychiatric events.

Johnson, D. S., & Li, J. J. (n.d.). Neuraminidase Inhibitors for Influenza: Oseltamivir Phosphate (Tamiflu®) and Zanamivir (Relenza®). The Art of Drug Synthesis, 95–114. doi: 10.1002/9780470134979.ch7
Lehnert, R., Pletz, M., Reuss, A., & Schaberg, T. (2016). Antiviral Medications in Seasonal and Pandemic Influenza. Deutsches Aerzteblatt Online. doi: 10.3238/arztebl.2016.0799

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